群馬大学 大学院保健学研究科 医学部保健学科

本文ヘジャンプします"
  • キャンパスマップ
  • サイトマップ
  • お問い合わせ
  • アクセスマップ
  • 日本語
  • English

保健学科について / 保健学研究科について

プロフィール 教育と研究 臨床業務、地域・国際貢献 業 績

▌プロフィール

土橋 邦生
どばし くにお 土橋 邦生 Kunio Dobashi リハビリテーション領域 基礎保健学ユニット
現 職
群馬大学医学部保健学科教授、大学院教務委員会 委員長
資 格
日本呼吸器学会―専門医、日本アレルギー学会―専門医、インフェクション コントロール ドクター、日本内科学会認定医
所属学会
日本内科学会会員、日本呼吸器学会会員(代議員)、日本アレルギー学会会員(理事、広報委員会委員長)、 日本癌学会会員、日本肺癌学会会員、日本結核病学会会員、日本感染症学会会員、 日本免疫学会会員、日本呼吸ケア・リハビリテーション学会(代議員)、日本職業・環境アレルギー学会(理事、編集委員長)、日本臨床腫瘍学会会員 国際喘息学会会員(日本支部長) 米国胸部疾患学会会員、欧州呼吸器学会会員
コメント
研究テーマは、各種呼吸器疾患(喘息、COPD、がん、感染症)発症への、酸化ストレスの関与を、人の吸気中に含まれる成分の測定や、培養細胞を使った研究をしています。また、慢性呼吸器疾患の呼吸リハビリテーションの有効性の検討をしています。さらに、アスベスト吸入の肺への影響についての研究しています。

▌教育と研究

研究内容

呼吸器疾患、アレルギー疾患を中心に、生化学的、免疫学的手法を使い研究している。

  1. 慢性呼吸器疾患に対する、呼吸器リハビリテーションの有効性につき、患者の呼吸機能の改善度や、呼気ガス・血液中に含まれる各種サイトカイン・炎症性物質の変化を測定することによる検証。
  2. 量子ビームを使用した石綿肺の病態の解明と早期診断法の開発
  3. 酸化ストレスの呼吸器疾患に与える影響に関し、主に細胞内刺激伝達系に与える影響を生化学的、分子生物学的に検討している。
教育業務
学部教育

老年医学、臨床病態学、教養総合科目保健学科
(医学科)呼吸器内科学の講義
(保健学科理学療法専攻)卒業研究の指導

大学院教育

(前期課程:基礎理学療法学特別研究 後期課程:基礎理学・作業療法学特別研究)

呼吸器疾患に関する高度な基礎知識の教授と研究指導

▌臨床業務、地域・国際貢献

臨床業務

附属病院にて
・呼吸器・アレルギー内科外来―週2回
・アスベスト外来―週1回
・肺腫瘍カンファレンスー週1回

地域・国際貢献

群馬県アスベスト健診事業専門委員会委員、群馬県結核診査協議会委員
厚生労働省および日本呼吸器学会:重篤副作用疾患別対応マニュアル作成委員会委員
日本産業衛生学会:感作性物質分類小委員会委員
日本アレルギー学会:喘息予防・管理ガイドライン2006作成委員会委員

▌業 績

  1. Co-localization of iron binding on silica with p62/sequestosome1 (SQSTM1) in lung granulomas of mice with acute silicosis.
    Shimizu Y, Dobashi K, Nagase H, Ohta K, Sano T, Matsuzaki S, Ishii Y, Satoh T, Koka M, Yokoyama A, Ohkubo T, Ishii Y, Kamiya T.
    J Clin Biochem Nutr. 2015 Jan;56(1):74-83
  2. ROCK activation in lung of idiopathic pulmonary fibrosis with oxidative stress.
    Shimizu Y, Dobashi K, Sano T, Yamada M.
    Int J Immunopathol Pharmacol. 2014 Jan-Mar;27(1):37-44
  3. Safety and efficacy of high-dose leukocytapheresis in patients with refractory asthma.
    Ishizuka T, Hisada T, Hatori M, Koike A, Hanabuchi K, Matsuzaki S, Kamide Y, Utsugi M, Aoki H, Yoshino R, Yanagitani N, Koga Y, Ono A, Kaira K, Sunaga N, Dobashi K, Tsuburai T, Akiyama K, Yamada M, Suzuki K, Mori M.
    Inflamm Res. 2014 Sep;63(9):789-96.
  4. Japanese Guideline for Occupational Allergic Diseases 2014.
    Dobashi K, Akiyama K, Usami A, Yokozeki H, Ikezawa Z, Tsurikisawa N, Nakamura Y, Sato K, Okumura J; Committee for Japanese Guideline for Diagnosis and Management of Occupational Allergic Diseases; Japanese Society of Allergology.
    Allergol Int. 2014 Sep;63(3):421-42.
  5. The effects of concomitant GERD, dyspepsia, and rhinosinusitis on asthma symptoms and FeNO in asthmatic patients taking controller medications.
    Ishizuka T, Hisada T, Kamide Y, Aoki H, Seki K, Honjo C, Sakai H, Kadowaki M, Umeda Y, Morikawa M, Anzai M, Ameshima S, Ishizaki T, Dobashi K, Yamada M, Kusano M.
    J Asthma Allergy. 2014 Sep 5;7:131-9.
  6. Gastrointestinal symptoms in idiopathic pulmonary fibrosis patients treated with pirfenidone and herbal medicine.
    Shimizu Y, Shimoyama Y, Kawada A, Kusano M, Hosomi Y, Sekiguchi M, Kawata T, Horie T, Ishii Y, Yamada M, Dobashi K, Takise A.
    J Biol Regul Homeost Agents. 2014 Jul-Sep;28(3):433-42.
  7. Oxidative stress potentially enhances FcεRI-mediated leukotriene C4 release dependent on the late-phase increase of intracellular glutathione in mast cells.
    Seki K, Hisada T, Kawata T, Kamide Y, Dobashi K, Yamada M, Mori M, Okajima F, Ishizuka T.
    Biochem Biophys Res Commun. 2013 Sep 27;439(3):357-62
  8. Shimizu Y, Dobashi K.. CC-chemokine CCL15 expression and possible implications for the pathogenesis of IgE-related severe asthma. Mediators Inflamm. 2012;2012:475253. doi: 10.1155/2012/475253. Epub 2012 Oct 31.
  9. Shimizu Y, Dobashi K. Proton ion-microbeam elemental analysis for inhaled particle-induced pulmonary diseases: application for diagnosis and assessment of progression. Curr Med Chem. 2013 Feb 1;20(6):789-93.
  10. Hasegawa M, Dobashi K, Horie T, Wada N, Shirakura K. Influence of inhaled procaterol on pulmonary rehabilitation in chronic obstructive pulmonary disease. Respir Investig. 2012 Dec;50(4):135-9. doi: 10.1016/j.resinv.2012.08.003. Epub 2012 Sep 13.
  11. Dobashi K. Occupational asthma in Japan.. Asia Pac Allergy. 2012 Jul;2(3):173-80. doi: 10.5415/apallergy.2012.2.3.173.
  12. Shimizu Y, Dobashi K, Kusano M, Mori M.. Different gastoroesophageal reflux symptoms of middle-aged to elderly asthma and chronic obstructive pulmonary disease (COPD) patients. J Clin Biochem Nutr. 2012 Mar;50(2):169-75. doi: 10.3164/jcbn.11-75. Epub 2011 Nov 11.
  13. Shimizu Y, Matsuzaki S, Satoh T, Koka M, Yokoyama A, Ohkubo T, Ishii Y, Kamiya T, Fueki M, Mori M, Dobashi K. In-air microparticle induced X-ray emission analysis of particles in interstitial pneumonia lung tissue obtained by transbronchial biopsy. J Clin Biochem Nutr. 2011 Sep;49(2):125-30. doi: 10.3164/jcbn.10-127. Epub 2011 Jul 13.
  14. Ishizuka T, Matsuzaki S, Aoki H, Yatomi M, Kamide Y, Hisada T, Tsuburai T, Dobashi K, Ohshima K, Akiyama K, Mori M. Prevalence of asthma symptoms based on the European Community Respiratory Health Survey questionnaire and FENO in university students: gender differences in symptoms and FENO. Allergy Asthma Clin Immunol. 2011 Sep 19;7(1):15. doi: 10.1186/1710-1492-7-15.
  15. Matsuzaki S, Ishizuka T, Yamada H, Kamide Y, Hisada T, Ichimonji I, Aoki H, Yatomi M, Komachi M, Tsurumaki H, Ono A, Koga Y, Dobashi K, Mogi C, Sato K, Tomura H, Mori M, Okajima F.. Extracellular acidification induces connective tissue growth factor production through proton-sensing receptor OGR1 in human airway smooth muscle cells. Biochem Biophys Res Commun. 2011 Oct 7;413(4):499-503. doi: 10.1016/j.bbrc.2011.08.087. Epub 2011 Sep 1.
  16. Shimizu Y, Dobashi K, Fueki N, Fueki M, Okada T, Tomioka S, Makino S, Mori M. Changes of immunomodulatory cytokines associated with omalizumab therapy for severe persistent asthma. J Biol Regul Homeost Agents. 2011 Apr-Jun;25(2):177-86.
  17. Shimizu Y, Matsuzaki S, Dobashi K, Yanagitani N, Satoh T, Koka M, Yokoyama A, Ohkubo T, Ishii Y, Kamiya T, Mori M. Elemental analysis of lung tissue particles and intracellular iron content of alveolar macrophages in pulmonary alveolar proteinosis. Respir Res. 2011 Jun 30;12:88. doi: 10.1186/1465-9921-12-88.
  18. Shimizu Y, Matsuzaki S, Mori M, Dobashi K. Chronic exposure to particles caused bronchioloalveolar carcinoma in a patient with cryptogenic organizing pneumonia evaluated by elemental analysis. Immunopharmacol Immunotoxicol. 2012 Feb;34(1):170-3. doi: 10.3109/08923973.2011.587434. Epub 2011 Jun 16.
  19. Kamide Y, Utsugi M, Dobashi K, Ono A, Ishizuka T, Hisada T, Koga Y, Uno K, Hamuro J, Mori M. Intracellular glutathione redox status in human dendritic cells regulates IL-27 production and T-cell polarization. Allergy. 2011 Sep;66(9):1183-92. doi: 10.1111/j.1398-9995.2011.02611.x. Epub 2011 May 5.
  20. Shimizu Y, Matsuzaki S, Satoh T, Ohkubo T, Yokoyama A, Ishii Y, Kamiya T, Arakawa K, Shimizu K, Tanaka S, Mori M, Dobashi K. Influence of tissue particles on Fas expression in idiopathic interstitial pneumonia. Front Biosci (Elite Ed). 2011 Jan 1;3:65-73.
  21. Matsuzaki S, Ishizuka T, Hisada T, Aoki H, Komachi M, Ichimonji I, Utsugi M, Ono A, Koga Y, Dobashi K, Kurose H, Tomura H, Mori M, Okajima F.. Lysophosphatidic acid inhibits CC chemokine ligand 5/RANTES production by blocking IRF-1-mediated gene transcription in human bronchial epithelial cells. J Immunol. 2010 Oct 15;185(8):4863-72. doi: 10.4049/jimmunol.1000904. Epub 2010 Sep 22.
  22. Aoki H, Hisada T, Ishizuka T, Utsugi M, Ono A, Koga Y, Sunaga N, Nakakura T, Okajima F, Dobashi K, Mori M.. Protective effect of resolvin E1 on the development of asthmatic airway inflammation. Biochem Biophys Res Commun. 2010 Sep 10;400(1):128-33. doi: 10.1016/j.bbrc.2010.08.025. Epub 2010 Aug 12.
  23. Ichimonji I, Tomura H, Mogi C, Sato K, Aoki H, Hisada T, Dobashi K, Ishizuka T, Mori M, Okajima F.. Extracellular acidification stimulates IL-6 production and Ca(2+) mobilization through proton-sensing OGR1 receptors in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2010 Oct;299(4):L567-77. doi: 10.1152/ajplung.00415.2009. Epub 2010 Jul 23.
  24. Shimizu Y, Dobashi K, Endou K, Ono A, Yanagitani N, Utsugi M, Sano T, Ishizuka T, Shimizu K, Tanaka S, Mori M. Decreased interstitial FOXP3(+) lymphocytes in usual interstitial pneumonia with discrepancy of CXCL12/CXCR4 axis. Int J Immunopathol Pharmacol. 2010 Apr-Jun;23(2):449-61.
  25. Utsugi M, Dobashi K, Ono A, Ishizuka T, Hisada T, Koga Y, Shimizu Y, Kawata T, Matsuzaki S, Aoki H, Kamide Y, Mori M. JNK1 and JNK2 differently regulate IL-12 production in THP-1 macrophage cells. Cytokine. 2010 Aug;51(2):127-31. doi: 10.1016/j.cyto.2010.04.002. Epub 2010 May 18.
  26. Yanagitani N, Shimizu Y, Kazama T, Dobashi K, Ishizuka T, Mori M. Eosinophilic bronchiolitis indicating eosinophilic airway disease with overexpression of carcinoembryonic antigen in sinus and bronchiole: case report. J Biol Regul Homeost Agents. 2010 Jan-Mar;24(1):99-102.
  27. Matsuzaki S, Shimizu Y, Dobashi K, Nagamine T, Satoh T, Ohkubo T, Yokoyama A, Ishii Y, Kamiya T, Arakawa K, Makino S, Utsugi M, Ishizuka T, Tanaka S, Shimizu K, Mori M. Analysis on the co-localization of asbestos bodies and Fas or CD163 expression in asbestos lung tissue by in-air micro-pixe. Int J Immunopathol Pharmacol. 2010 Jan-Mar;23(1):1-11.
  28. Kuribayashi S, Kusano M, Kawamura O, Shimoyama Y, Maeda M, Hisada T, Ishizuka T, Dobashi K, Mori M. Mechanism of gastroesophageal reflux in patients with obstructive sleep apnea syndrome. Neurogastroenterol Motil. 2010 Jun;22(6):611-e172. doi: 10.1111/j.1365-2982.2010.01485.x. Epub 2010 Mar 15.
  29. Shimizu Y, Dobashi K, Nagoshi A, Kawamura O, Mori M. Assessment of airway inflammation by exhaled breath condensate and impedance due to gastroesophageal reflux disease (GERD). Inflamm Allergy Drug Targets. 2009 Sep;8(4):292-6. Review.
  30. Utsugi M, Dobashi K, Ono A, Ishizuka T, Matsuzaki S, Hisada T, Shimizu Y, Kawata T, Aoki H, Kamide Y, Mori M. PI3K p110beta positively regulates lipopolysaccharide-induced IL-12 production in human macrophages and dendritic cells and JNK1 plays a novel role.. J Immunol. 2009 May 1;182(9):5225-31
  31. Shimizu Y, Dobashi K, Imai H, Sunaga N, Ono A, Sano T, Hikino T, Shimizu K, Tanaka S, Ishizuka T, Utsugi M, Mori M.. CXCR4+FOXP3+CD25+ lymphocytes accumulate in CXCL12-expressing malignant pleural mesothelioma. Int J Immunopathol Pharmacol. 2009 Jan-Mar;22(1):43-51.
  32. Ono A, Utsugi M, Masubuchi K, Ishizuka T, Kawata T, Shimizu Y, Hisada T, Hamuro J, Mori M, Dobashi K. Glutathione redox regulates TGF-beta-induced fibrogenic effects through Smad3 activation. FEBS Lett. 2009 Jan 22;583(2):357-62. doi: 10.1016/j.febslet.2008.12.021. Epub 2008 Dec 25.
  33. Shimizu Y, Dobashi K, Kusakbe T, Nagamine T, Oikawa M, Satoh T, Haga J, Ishii Y, Ohkubo T, Kamiya T, Arakawa K, Sano T, Tanaka S, Shimizu K, Matsuzaki S, Utsugi M, Mori M.. In-air micro-particle induced X-ray emission analysis of asbestos and metals in lung tissue. Int J Immunopathol Pharmacol. 2008 Jul-Sep;21(3):567-76
  34. Shimizu Y, Dobashi K, Yoshikawa Y, Yabe S, Higuchi S, Koike Y, Mita Y, Utsugi M, Endou K, Takahashi K, Watanabe S, Saito R, Mori M. Five-antituberculosis Drug-resistance Genes Detection Using Array System. J Clin Biochem Nutr. 2008 May;42(3):228-34.
  35. Shimizu Y, Dobashi K, Mori M. Exhaled breath marker in asthma patients with gastroesophageal reflux disease. J Clin Biochem Nutr. 2007 Nov;41(3):147-53.
  36. Aoki H, Hisada T, Ishizuka T, Utsugi M, Kawata T, Shimizu Y, Okajima F, Dobashi K, Mori M. Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma. Biochem Biophys Res Commun. 2008 Mar 7;367(2):509-15.
  37. Ishizuka T, Hisada T, Aoki H, Yanagitani N, Kaira K, Utsugi M, Shimizu Y, Sunaga N, Dobashi K, Mori M. Gender and age risks for hoarseness and dysphonia with use of a dry powder fluticasone propionate inhaler in asthma. Allergy Asthma Proc. 2007 Sep-Oct;28(5):550-6.
  38. Shimizu Y, Dobashi K, Hisada T, Ono A, Todokoro M, Iijima H, Utsugi M, Kakegawa S, Iizuka K, Ishizuka T, Morikawa A, Mori M. Acute impact of volcanic ash on asthma symptoms and treatment.. Int J Immunopathol Pharmacol. 2007 Apr-Jun;20(2 Suppl 2):9-14
  39. Kaira K, Oriuchi N, Otani Y, Shimizu K, Tanaka S, Imai H, Yanagitani N, Sunaga N, Hisada T, Ishizuka T, Dobashi K, Kanai Y, Endou H, Nakajima T, Endo K, Mori M. Fluorine-18-alpha-methyltyrosine positron emission tomography for diagnosis and staging of lung cancer: a clinicopathologic study. Clin Cancer Res. 2007 Nov 1;13(21):6369-78.
  40. Kaira K, Dobashi K, Yanagitani N, Sunaga N, Shimizu Y, Hisada T, Ishizuka T, Nakajima T, Mori M. Rapid growth of malignant pleural mesothelioma. J Thorac Oncol. 2007 Oct;2(10):966-7.
  41. Koike Y, Hisada T, Utsugi M, Ishizuka T, Shimizu Y, Ono A, Murata Y, Hamuro J, Mori M, Dobashi K. Glutathione redox regulates airway hyperresponsiveness and airway inflammation in mice. Am J Respir Cell Mol Biol. 2007 Sep;37(3):322-9. Epub 2007 May 16.
  42. Shimizu Y, Dobashi K, Zhao JJ, Kawata T, Ono A, Yanagitani N, Kaira K, Utsugi M, Hisada T, Ishizuka T, Mori M. Proton pump inhibitor improves breath marker in moderate asthma with gastroesophageal reflux disease. Respiration. 2007;74(5):558-64. Epub 2007 Mar 27.
  43. Sunaga N, Tomizawa Y, Yanagitani N, Iijima H, Kaira K, Shimizu K, Tanaka S, Suga T, Hisada T, Ishizuka T, Saito R, Dobashi K, Mori M. Phase II prospective study of the efficacy of gefitinib for the treatment of stage III/IV non-small cell lung cancer with EGFR mutations, irrespective of previous chemotherapy. Lung Cancer. 2007 Jun;56(3):383-9. Epub 2007 Mar 26.
  44. Utsugi M, Dobashi K, Ishizuka T, Kawata T, Hisada T, Shimizu Y, Ono A, Mori M.
    Rac1 negatively regulates lipopolysaccharide-induced IL-23 p19 expression in human macrophages and dendritic cells and NF-kappaB p65 trans activation plays a novel role
    J Immunol.Oct 1;177(7):4550-7.(2006)
  45. Shimizu Y, Dobashi K, Mita Y, Endou K, Moriya S, Osano K, Koike Y, Higuchi S, Yabe S, Utsugi M, Ishizuka T, Hisada T, Nakazawa T, Mori M
    DNA microarray genotyping of N-acetyltransferase 2 polymorphism using carbodiimide as the linker for assessment of isoniazid hepatotoxicity
    Tuberculosis (Edinb). Sep;86(5):374-81. (2006)
  46. Shimizu Y, Kuwabara H, Ono A, Higuchi S, Hisada T, Dobashi K, Utsugi M, Mita Y, Mori M
    Intracellular Th1/Th2 balance of pulmonary CD4(+) T cells in patients with active interstitial pneumonia evaluated by serum KL-6.
    Immunopharmacol Immunotoxicol.28(2):295-304. (2006)
  47. Iijima H, Tomizawa Y, Iwasaki Y, Sato K, Sunaga N, Dobashi K, Saito R, Nakajima T, Minna JD, Mori M
    Genetic and epigenetic inactivation of LTF gene at 3p21.3 in lung cancers.
    Int J Cancer. Feb 15;118(4):797-801. (2006)
  48. Kawata T, Ishizuka T, Tomura H, Hisada T, Dobashi K,
    Tsukagoshi H,Ishiwara M, Kurose H, Mori M, Okajima F.
    Sphingosine 1-phosphateinhibits migration and RANTES productionin human bronchial smooth muscle cells.
    Biochem Biophys Res Commun.331(2):640-7.(2005)
  49. Tomizawa Y, Iijima H, Sunaga N, Sato K, Takise A, Otani Y, Tanaka S, Suga T, Saito R, Ishizuka T, Dobashi K, Minna JD, Nakajima T, Mori M.Clinicopathologic significance of the mutations of the epidermalgrowth factor receptor gene in patients with non-small cell lung cancer.
    Clin Cancer Res. 11 (19 Pt 1):6816-22. (2005)
  50. Ishizuka T. Kawata T. Shimizu Y. Utsugi M. Endou K. Hisada T. Dobashi K. Nakazawa T. and Mori M.
    Safety and efficacy of extracorporeal granulocyte and monocyte adsorption apheresis in patients with severe persistent bronchial asthma.
    Inflammation. Feb;29(1):9-16.(2005)
  51. Todokoro M, Mochizuki H, Tokuyama K, Utsugi M, Dobashi K, Mori M,Morikawa A.
    Effect of ozone exposure on intracellular glutathione redox state in cultured human airway epithelial cells.
    Inflammation. 28(2):105-14. (2004)
  52. Aihara M, Dobashi K, Iizuka K, Nakazawa T, Mori M.
    Effect of Y-27632 on release of cytokines from peripheral T cells in asthmatic patients and normal subjects.
    Int Immunopharmacol. 4(4):557-61. (2004)
  53. Endou K, Iizuka K, Yoshii A, Tsukagoshi H, Ishizuka T,
    Dobashi K, Nakazawa T, Mori M. 8-Bromo-cAMP decreases the Ca2+ sensitivity of airway smooth muscle contraction through a mechanism distinct from inhibition of Rho-kinase. Am J Physiol Lung Cell Mol Physiol. 287(4):L641-8. (2004)
  54. Tomizawa Y, Iijima H, Nomoto T, Iwasaki Y, Otani Y, Tsuchiya S,
    Saito R, Dobashi K, Nakajima T, Mori M.
    Clinicopathological significance of aberrant methylation of RARbeta2 at 3p24, RASSF1A at 3p21.3, and FHIT at 3p14.2 in patients with non-small cell lung cancer.
    Lung Cancer.46(3):305-12.(2004)
  55. Iijima H, Tomizawa Y, Dobashi K, Saito R, Nakajima T, Mori M.
    Allelic losses on chromosome 3p are accumulated in relation to morphological changes of lung adenocarcinoma.
    Br J Cancer. Sep 13;91(6):1143-8. (2004)
  56. Utsugi M, Dobashi K, Ishizuka T, Endou K, Hamuro J, Murata Y,
    Nakazawa T, Mori M.
    C-Jun-NH2-terminal kinase negatively regulates lipopolysaccaride- induced IL-12production in human macrophages: role of mitogen activated protein kinase in glutathione redox regulation of IL-12 production.
    J Immunol.171(2):628-35. (2003)
  57. Utsugi M. Dobashi K, Ishizuka T. Masubuchi K.Shimizu Y. Nakazawa T. and Mori M. C-Jun-NH2-terminal kinases mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts.
    Am. J. Respir. Cell Mol. Biol. 28:754-761, (2003)
  58. Aihara M, Dobashi K, Iizuka K, Nakazawa T, Mori M.
    Comparison of effects of Y-27632 and Isoproterenol on release of cytokines from human peripheral T cells.
    Int Immunopharmacol. Nov;3(12):1619-25. (2003)
  59. Mita Y, Dobashi K, Endou K, Kawata T, Shimizu Y, Nakazawa T, Mori M.
    Toll-like receptor 4 surface expression on human monocytes and B cells is modulated by IL-2 and IL-4.
    Immunol Let. 81(1):71-5. (2002)
  60. Utsugi M. Dobashi,K. Koga Y. Shimizu, Y. Ishizuka, T. Hamuro J. Nakazawa,T, Mori, M. Glutathione redox regulates lipopolysaccharide- induced IL-12 production through p38 mitogen-activated protein kinase activation in human monocytes: role of glutathione redox in IFN-g priming of IL-12 production.
    J. Leuko. Biol 71:339-47. (2002)
  61. Mita Y, Dobashi K, Shimizu Y, Nakazawa T, Mori M.
    Surface expression of toll-like receptor 4 on THP-1 cells is modulated by Bu-Zhong-Yi-Qi-Tang and Shi-Quan-Da-Bu-Tang. Methods Find Exp Clin Pharmacol. 24(2):67-70, (2002)
  62. Tsukagoshi H, Kawata T, Shimizu Y, Ishizuka T, Dobashi K, Mori M. 4-Hydroxy-2-Nonenal Enhances Fibronectin Production by IMR-90 Human Lung Fibroblasts Partly via Activation of Epidermal Growth Factor Receptor-Linked Extracellular Signal-Regulated Kinase p44/42 Pathway.
    Toxicol Appl Pharmacol. 184(3):127-35, (2002)