群馬大学 大学院保健学研究科 医学部保健学科

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保健学科について / 保健学研究科について

プロフィール 教育と研究 臨床業務、地域・国際貢献 業 績

▌プロフィール

松井 弘樹
まつい ひろき 松井 弘樹 Hiroki Matsui 応用保健学ユニット 生体情報検査学領域 E-mail website

現 職群馬大学大学院保健学研究科 講師資 格臨床検査技師所属学会アメリカ心臓学会、日本循環器学会、日本超音波検査学会、日本統合医療学会、日本未病システム学会、日本保健医療福祉連携教育学会、日本臨床衛生検査技師会コメント生理機能検査の授業および実習を主に担当しております。また、肥満・糖尿病が心疾患、動脈硬化および呼吸器疾患などに及ぼすリスクについて、分子レベルによる解析と生理機能検査を併せて検討することで、生活習慣病の予防へ向けた研究をしております。

▌教育と研究

研究内容

肥満や糖尿病患者で認められる脂肪酸の量的変化だけでなく、飽和脂肪酸・不飽和脂肪酸といった質的変化と、その組成を調節する酵素であるStearoyl-CoA desaturase-1(SCD1)、Elongation of long chain fatty acid member 6 (Elovl6)に着目し、心血管系疾患や呼吸器疾患に対する病態意義について検討を行っております。

教育業務

生体機能学実習、臨床生体機能学実習、臨床生体機能学演習、病院演習Ⅲ
チームワーク実習、チームワーク原論、チーム医療(教養教育)、統合保健医療論

▌臨床業務、地域・国際貢献

地域・国際貢献
  • WHO協力センター 多職種連携教育推進室委員
  • 保健学研究科 地域保健推進室委員

▌業 績

  1. Putri M, Syamsunarno MR, Iso T, Yamaguchi A, Hanaoka H, Sunaga H, Koitabashi N, Matsui H, Yamazaki C, Kameo S, Tsushima Y, Yokoyama T, Koyama H, Abumrad NA, Kurabayashi M. CD36 is indispensable for thermogenesis under conditions of fasting and cold stress. Biochem Biophys Res Commun. 457(4):520-5. 2015.
  2. Syamsunarno MR, Iso T, Yamaguchi A, Hanaoka H, Putri M, Obokata M, Sunaga H, Koitabashi N, Matsui H, Maeda K, Endo K, Tsushima Y, Yokoyama T, Kurabayashi M. Fatty Acid Binding Protein 4 and 5 Play a Crucial Role in Thermogenesis under the Conditions of Fasting and Cold Stress. PLoS One. 9(3): e90825, 2014.
  3. Sunaga H*, Matsui H*, Ueno M, Maeno T, Iso T, Syamsunarno MR, Anjo S, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M. (*Equal contribution) Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice. Nat Commun. 4:2563, 2013.
  4. Kageyama A, Matsui H, Ohta M, Sambuichi K, Kawano H, Notsu T, Imada K, Yokoyama T, Kurabayashi M. Palmitic Acid Induces Osteoblastic Differentiation in Vascular Smooth Muscle Cells through ACSL3 and NF-κB, Novel Targets of Eicosapentaenoic acid. PLoS One. 8(6):e68197, 2013.
  5. Syamsunarno MR, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M, Kobayashi M, Kikuchi O, Sasaki T, Maeda K, Murakami M, Kitamura T, Suematsu M, Tsushima Y, Endo K, Hotamisligil GS, Kurabayashi M. A Critical Role of Fatty Acid Binding Protein 4 and 5 (FABP4/5) in the Systemic Response to Fasting. PLoS One. 8(11): e79386, 2013.
  6. Iso T, Maeda K, Hanaoka H, Suga T, Goto K, Syamsunarno MR, Hishiki T, Nagahata Y, Matsui H, Arai M, Yamaguchi A, Abumrad NA, Sano M, Suematsu M, Endo K, Hotamisligil GS, Kurabayashi M. Capillary Endothelial Fatty Acid Binding Proteins 4 and 5 Play a Critical Role in Fatty Acid Uptake in Heart and Skeletal Muscle. Arterioscler Thromb Vasc Biol. 33:2549-57, 2013.
  7. Goto K, Iso T, Hanaoka H, Yamaguchi A, Suga T, Hattori A, Irie Y, Shinagawa Y, Matsui H, Syamsunarno MR, Matsui M, Haque A, Arai M, Kunimoto F, Yokoyama T, Endo K, Gonzalez FJ, Kurabayashi M. Peroxisome Proliferator-Activated Receptor-gamma in Capillary Endothelia Promotes Fatty Acid Uptake by Heart During Long-Term Fasting. J Am Heart Assoc. 2(1):e004861, 2013.
  8. Matsui H, Yokoyama T, Tanaka C, Sunaga H, Koitabashi N, Takizawa T, Arai M, Kurabayashi M. Pressure mediated hypertrophy and mechanical stretch up-regulate expression of the long form of leptin receptor (ob-Rb) in rat cardiac myocytes. BMC Cell Biology. 13:37, 2012.
  9. Matsui H, Yokoyama T, Sekiguchi K, Iijima D, Sunaga H, Maniwa M, Ueno M, Iso T, Arai M, Kurabayashi M. Stearoyl-CoA Desaturase-1 (SCD1) Augments Saturated Fatty Acid-induced Lipid Accumulation and Inhibits Apoptosis in Cardiac Myocytes. PLoS One. 7(3):e33283. 2012.
  10. Ohyama Y, Tanaka T, Shimizu T, Matsui H, Sato H, Koitabashi N, Doi H, Iso T, Arai M, Kurabayashi M. Runx2/Smad3 Complex Negatively Regulates TGF-β-Induced Connective Tissue Growth Factor gene Expression in Vascular Smooth Muscle Cells. J Atheroscler Thromb. 19(1): 23-35. 2012.
  11. Shimizu T, Tanaka T, Iso T, Matsui H, Ohyama Y, Kawai-Kowase K, Arai M, Kurabayashi M. Notch signaling pathway enhances bone morphogenetic protein 2 (BMP2) responsiveness of Msx2 gene to induce osteogenic differentiation and mineralization of vascular smooth muscle cells. J Biol Chem. 286(21):19138-48. 2011.
  12. Aoyagi-Ikeda K, Maeno T, Matsui H, Ueno M, Hara K, Aoki Y, Aoki F, Shimizu T, Doi H, Kawai-Kowase K, Iso T, Suga T, Arai M, Kurabayashi M. Notch induces myofibroblast differentiation of alveolar epithelial cells. Am. J. Respir. Cell Mol. Biol. 45(1):136-44. 2011.
  13. Ueno M, Maeno T, Nomura M, Aoyagi-Ikeda K, Matsui H, Hara K, Tanaka T, Iso T, Suga T, Kurabayashi M. Hypoxia-inducible factor-1α mediates TGF-β-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 300(5):L740-52. 2011.
  14. Nakahara T, Sato H, Shimizu T, Tanaka T, Matsui H, Kawai-Kowase K, Sato M, Iso T, Arai M, Kurabayashi M. Fibroblast Growth Factor 2 Induces Osteogenic Differentiation through a Runx2 Activation in Vascular Smooth Muscle Cells. Biochem Biophys Res Commun. 394(2):243-8. 2010.
  15. Kawai-Kowase K, Ohshima T, Matsui H, Tanaka T, Shimizu T, Iso T, Arai M, Owens GK, Kurabayashi M. PIAS1 mediates TGFβ-induced SM α-actin gene expression through inhibition of KLF4 function-expression by protein sumoylation. Arterioscler Thromb Vasc Biol. 29(1): 99-106. 2009.
  16. Tokuda F, Sando Y, Matsui H, Koike H, Yokoyama T. The serum levels of adipocytokines, Adiponectin and Leptin, in patients with obstractive sleep apnea syndrome. Internal Med. 48, 1843-49. 2008.
  17. Tanaka T, Sato H, Doi H, Yoshida CA, Shimizu T, Matsui H, Yamazaki M, Akiyama H, Kawai-Kowase K, Iso T, Komori T, Arai M, Kurabayashi M. Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells. Mol Cell Biol. 28(3), 1147-60. 2008.
  18. Matsui H, Motooka M, Koike H, Inoue M, Iwasaki T, Suzuki T, Kurabayashi M, Yokoyama T. Ischemia/reperfusion in rat heart induces leptin and leptin receptor gene expression. Life Science. 80, 672-80. 2007.
  19. Doi H, Iso T, Sato H, Yamazaki M, Matsui H, Tanaka T, Manabe I, Arai M, Nagai R, Kurabayashi M. Jagged1-selective notch signaling induces smooth muscle differentiation via RBP-Jkappa dependent pathway. J Biol Chem. 281(39), 28555-64. 2006.