群馬大学 大学院保健学研究科 医学部保健学科

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保健学科について / 保健学研究科について

プロフィール 教育と研究 臨床業務、地域・国際貢献 業 績

▌プロフィール

松井 弘樹
まつい ひろき 松井 弘樹 Hiroki Matsui 応用保健学ユニット 生体情報検査学領域 E-mail website

現 職
群馬大学大学院保健学研究科 准教授

資 格
臨床検査技師

所属学会
アメリカ心臓学会、日本循環器学会、日本超音波検査学会、日本統合医療学会、日本未病システム学会(評議員)、日本保健医療福祉連携教育学会、日本臨床衛生検査技師会、日本臨床化学会、北関東医学会

コメント

臨床検査総論、検査管理総論および生理機能検査の授業および実習を担当しております。また、肥満・糖尿病が心疾患や動脈硬化、呼吸器疾患などに及ぼす影響について、分子レベルによる解析と生理機能検査を併せて解析することで、生活習慣病の予防に向けた研究を行っております。

▌教育と研究

研究内容

肥満や糖尿病患者で認められる高遊離脂肪酸血症といった量的変化だけでなく、飽和脂肪酸・不飽和脂肪酸といった質的変化と、その組成を調節する酵素であるStearoyl-CoA desaturase-1(SCD1)、Elongation of long chain fatty acid member 6 (Elovl6)に着目し、心血管系疾患や呼吸器疾患に対する病態意義について検討を行っております。詳しくは本研究室のHPをご覧ください。
http://heart.health.gunma-u.ac.jp

教育業務

学部教育
臨床検査総論、臨床検査総論実習、検査管理総論、検査機器総論
生体機能学実習、臨床生体機能学実習、臨床生体機能学演習、病院演習Ⅲ
チームワーク実習、チームワーク原論、チーム医療(教養教育)、統合保健医療論

 

大学院教育
機能情報解析学特論、食の安全特論、生体情報検査科学特別セミナー

▌臨床業務、地域・国際貢献

地域・国際貢献
  • WHO協力センター 多職種連携教育推進室委員
  • 保健学研究科 地域保健推進室委員
  • 食健康科学教育研究センター 委員

▌業 績

  1. Sunaga H, Koitabashi N, Iso T, Matsui H, Obokata M, Kawakami R, Murakami M, Yokoyama T, Kurabayashi M. Activation of cardiac AMPK-FGF21 feed-forward loop in acute myocardial infarction: Role of adrenergic overdrive and lipolysis byproducts. Sci Rep. 9(1):11841. 2019
  2. Dharmawan T, Nakajima T, Iizuka T, Tamura S, Matsui H, Kaneko Y, Kurabayashi M. Enhanced closed-state inactivation of mutant cardiac sodium channels (SCN5A N1541D and R1632C) through different mechanisms. J Mol Cell Cardiol. 130:88-95. 2019.
  3. Masubuchi H, Ueno M, Maeno T, Yamaguchi K, Hara K, Sunaga H, Matsui H, Nagasawa M, Kojima I, Iwata Y, Wakabayashi S, Kurabayashi M. Reduced transient receptor potential vanilloid 2 expression in alveolar macrophages causes COPD in mice through impaired phagocytic activity. BMC Pulm Med. 19(1):70. 2019
  4. Iso T, Haruyama H, Sunaga H, Matsui M, Matsui H, Tanaka R, Umbarawan Y, Syamsunarno MRAA, Yokoyama T, Kurabayashi M. Exercise endurance capacity is markedly reduced due to impaired energy homeostasis during prolonged fasting in FABP4/5 deficient mice. BMC Physiol. 19(1):1. 2019.
  5. Iso T, Haruyama H, Sunaga H, Matsui H, Matsui M, Tanaka R, Umbarawan Y, Syamsunarno MRAA, Putri M, Yamaguchi A, Hanaoka H, Negishi K, Yokoyama T, Kurabayashi M. CD36 is indispensable for nutrient homeostasis and endurance exercise capacity during prolonged fasting. Physiol Rep. 6(19):e13884. 2018.
  6. Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Obinata H, Yamaguchi A, Hanaoka H, Hishiki T, Hayakawa N, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T. Myocardial fatty acid uptake through CD36 is indispensable for sufficient bioenergetic metabolism to prevent progression of pressure overload-induced heart failure. Sci Rep. 8(1):12035. 2018.
  7. Umbarawan Y, Syamsunarno MRAA, Koitabashi N, Yamaguchi A, Hanaoka H, Hishiki T, Nagahata-Naito Y, Obinata H, Sano M, Sunaga H, Matsui H, Tsushima Y, Suematsu M, Kurabayashi M, Iso T. Glucose is preferentially utilized for biomass synthesis in pressure-overloaded hearts: evidence from fatty acid-binding protein-4 and -5 knockout mice. Cardiovasc Res. 114(8):1132-1144. 2018
  8. Obokata M, Iso T, Ohyama Y, Sunaga H, Kawaguchi T, Matsui H, Iizuka T, Fukuda N, Takamatsu H, Koitabashi N, Funada R, Takama N, Kasama S, Kaneko Y, Yokoyama T, Murakami M, Kurabayashi M. Early increase in serum fatty acid binding protein 4 levels in patients with acute myocardial infarction. Eur Heart J Acute Cardiovasc Care. 7(6):561-569. 2018.
  9. Umbarawan Y, Syamsunarno MRAA, Obinata H, Yamaguchi A, Sunaga H, Matsui H, Hishiki T, Matsuura T, Koitabashi N, Obokata M, Hanaoka H, Haque A, Kunimoto F, Tsushima Y, Suematsu M, Kurabayashi M, Iso T. Robust suppression of cardiac energy catabolism with marked accumulation of energy substrates during lipopolysaccharide-induced cardiac dysfunction in mice. Metabolism. 77:47-57. 2017.
  10. Iso T, Sunaga H, Matsui H, Kasama S, Oshima N, Haruyama H, Furukawa N, Nakajima K, Machida T, Murakami M, Yokoyama T, Kurabayashi M.. Serum levels of fatty acid binding protein 4 and fat metabolic markers in relation to catecholamines following exercise. Clin Biochem. 50(16-17):896-902. 2017.
  11. Sunaga H, Matsui H, Anjo S, Syamsunarno MR, Koitabashi N, Iso T, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M. [※Equal contribution] Elovl6-driven Fatty Acid Metabolism Regulates Vascular Smooth Muscle Cell Phenotype through AMPK/KLF4 Signaling. J Am Heart Assoc. 5(12). pii: e004014. 2016.
  12. Nakahara T, Kawai-Kowase K, Matsui H, Sunaga H, Utsugi T, Iso T, Arai M, Tomono S, Kurabayashi M. Fibroblast growth factor 23 inhibits osteoblastic gene expression and induces osteoprotegerin in vascular smooth muscle cells. Atherosclerosis. 253: 102-110. 2016
  13. Putri M, Syamsunarno MR, Iso T, Yamaguchi A, Hanaoka H Sunaga H, Koitabashi N, Matsui H, Yamazaki C, Kameo S, Tsushima Y, Yokoyama T, Koyama H, Abumrad NA, Kurabayashi M. CD36 is indispensable for thermogenesis under conditions of fasting and cold stress. Biochem Biophys Res Commun. 457(4):520-5. 2015.
  14. Syamsunarno MR, Iso T, Yamaguchi A, Hanaoka H, Putri M, Obokata M, Sunaga H, Koitabashi N, Matsui H, Maeda K, Endo K, Tsushima Y, Yokoyama T, Kurabayashi M. Fatty Acid Binding Protein 4 and 5 Play a Crucial Role in Thermogenesis under the Conditions of Fasting and Cold Stress. PLoS One. 9(3): e90825, 2014.
  15. Sunaga H, Matsui H, Ueno M, Maeno T, Iso T, Syamsunarno MR, Anjo S, Matsuzaka T, Shimano H, Yokoyama T, Kurabayashi M. [※Equal contribution] Deranged fatty acid composition causes pulmonary fibrosis in Elovl6-deficient mice. Nat Commun. 4:2563, 2013.
  16. Kageyama A, Matsui H, Ohta M, Sambuichi K, Kawano H, Notsu T, Imada K, Yokoyama T, Kurabayashi M. Palmitic Acid Induces Osteoblastic Differentiation in Vascular Smooth Muscle Cells through ACSL3 and NF-κB, Novel Targets of Eicosapentaenoic acid. PLoS One. 8(6):e68197, 2013.
  17. Syamsunarno MR, Iso T, Hanaoka H, Yamaguchi A, Obokata M, Koitabashi N, Goto K, Hishiki T, Nagahata Y, Matsui H, Sano M, Kobayashi M, Kikuchi O, Sasaki T, Maeda K, Murakami M, Kitamura T, Suematsu M, Tsushima Y, Endo K, Hotamisligil GS, Kurabayashi M. A Critical Role of Fatty Acid Binding Protein 4 and 5 (FABP4/5) in the Systemic Response to Fasting. PLoS One. 8(11): e79386, 2013.
  18. Iso T, Maeda K, Hanaoka H, Suga T, Goto K, Syamsunarno MR, Hishiki T, Nagahata Y, Matsui H, Arai M, Yamaguchi A, Abumrad NA, Sano M, Suematsu M, Endo K, Hotamisligil GS, Kurabayashi M. Capillary Endothelial Fatty Acid Binding Proteins 4 and 5 Play a Critical Role in Fatty Acid Uptake in Heart and Skeletal Muscle. Arterioscler Thromb Vasc Biol. 33:2549-57, 2013.
  19. Goto K, Iso T, Hanaoka H, Yamaguchi A, Suga T, Hattori A, Irie Y, Shinagawa Y, Matsui H, Syamsunarno MR, Matsui M, Haque A, Arai M, Kunimoto F, Yokoyama T, Endo K, Gonzalez FJ, Kurabayashi M. Peroxisome Proliferator-Activated Receptor-gamma in Capillary Endothelia Promotes Fatty Acid Uptake by Heart During Long-Term Fasting. J Am Heart Assoc. 2(1):e004861, 2013.
  20. Matsui H, Yokoyama T, Tanaka C, Sunaga H, Koitabashi N, Takizawa T, Arai M, Kurabayashi M. Pressure mediated hypertrophy and mechanical stretch up-regulate expression of the long form of leptin receptor (ob-Rb) in rat cardiac myocytes. BMC Cell Biology. 13:37, 2012.
  21. Matsui H, Yokoyama T, Sekiguchi K, Iijima D, Sunaga H, Maniwa M, Ueno M, Iso T, Arai M, Kurabayashi M. Stearoyl-CoA Desaturase-1 (SCD1) Augments Saturated Fatty Acid-induced Lipid Accumulation and Inhibits Apoptosis in Cardiac Myocytes. PLoS One. 7(3):e33283. 2012.
  22. Ohyama Y, Tanaka T, Shimizu T, Matsui H, Sato H, Koitabashi N, Doi H, Iso T, Arai M, Kurabayashi M. Runx2/Smad3 Complex Negatively Regulates TGF-β-Induced Connective Tissue Growth Factor gene Expression in Vascular Smooth Muscle Cells. J Atheroscler Thromb. 19(1): 23-35. 2012.
  23. Shimizu T, Tanaka T, Iso T, Matsui H, Ohyama Y, Kawai-Kowase K, Arai M, Kurabayashi M. Notch signaling pathway enhances bone morphogenetic protein 2 (BMP2) responsiveness of Msx2 gene to induce osteogenic differentiation and mineralization of vascular smooth muscle cells. J Biol Chem. 286(21):19138-48. 2011.
  24. Aoyagi-Ikeda K, Maeno T, Matsui H, Ueno M, Hara K, Aoki Y, Aoki F, Shimizu T, Doi H, Kawai-Kowase K, Iso T, Suga T, Arai M, Kurabayashi M. Notch induces myofibroblast differentiation of alveolar epithelial cells. Am. J. Respir. Cell Mol. Biol. 45(1):136-44. 2011.
  25. Ueno M, Maeno T, Nomura M, Aoyagi-Ikeda K, Matsui H, Hara K, Tanaka T, Iso T, Suga T, Kurabayashi M. Hypoxia-inducible factor-1α mediates TGF-β-induced PAI-1 production in alveolar macrophages in pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 300(5):L740-52. 2011.
  26. Nakahara T, Sato H, Shimizu T, Tanaka T, Matsui H, Kawai-Kowase K, Sato M, Iso T, Arai M, Kurabayashi M. Fibroblast Growth Factor 2 Induces Osteogenic Differentiation through a Runx2 Activation in Vascular Smooth Muscle Cells. Biochem Biophys Res Commun. 394(2):243-8. 2010.
  27. Kawai-Kowase K, Ohshima T, Matsui H, Tanaka T, Shimizu T, Iso T, Arai M, Owens GK, Kurabayashi M. PIAS1 mediates TGFβ-induced SM α-actin gene expression through inhibition of KLF4 function-expression by protein sumoylation. Arterioscler Thromb Vasc Biol. 29(1): 99-106. 2009.
  28. Tokuda F, Sando Y, Matsui H, Koike H, Yokoyama T. The serum levels of adipocytokines, Adiponectin and Leptin, in patients with obstractive sleep apnea syndrome. Internal Med. 48, 1843-49. 2008.
  29. Tanaka T, Sato H, Doi H, Yoshida CA, Shimizu T, Matsui H, Yamazaki M, Akiyama H, Kawai-Kowase K, Iso T, Komori T, Arai M, Kurabayashi M. Runx2 represses myocardin-mediated differentiation and facilitates osteogenic conversion of vascular smooth muscle cells. Mol Cell Biol. 28(3), 1147-60. 2008.
  30. Matsui H, Motooka M, Koike H, Inoue M, Iwasaki T, Suzuki T, Kurabayashi M, Yokoyama T. Ischemia/reperfusion in rat heart induces leptin and leptin receptor gene expression. Life Science. 80, 672-80. 2007.
  31. Doi H, Iso T, Sato H, Yamazaki M, Matsui H, Tanaka T, Manabe I, Arai M, Nagai R, Kurabayashi M. Jagged1-selective notch signaling induces smooth muscle differentiation via RBP-Jkappa dependent pathway. J Biol Chem. 281(39), 28555-64. 2006.